Category Archives: Aesthetics

Vytrus Biotech launches new skin repairing active ingredient

Wax Selection – Leaders in Pharma, Biotech & MedTech Recruitment

An excess and accumulation of fat can have very negative effects on skin and body, accelerating ageing and creating sagging of the skin, among others.

Vytrus Biotech presents SARCOSLIM RE-SHAPE PRCF, an active ingredient that introduces the new concept of Liposculpture: a skin remodelling system that helps reduce fat, while taking advantage of the intercellular energy released through the burning of this fat to tighten and reaffirm tissue, so specific parts of the body can be sculpted at will.

The skin acquires a younger and firmer aspect from the ‘inside’. Liposculpting is exactly what the company’s new active achieves: reshaping your curves at will, while improving your skin structure.

The ingredient SARCOSLIM RE-SHAPE PRCF (INCI name: Sarcocapnos Crassifolia callus lysate), is made from totipotent cells (plant stem cells) of the endemic, and close to extinction South-Iberian plant, Sarcocapnos crassifolia, through the company’s technology platform, PLANT CELL BIOFACTORIES.

This active is a metabolome rich in plant lipid management related factors (fumaric acid: skin regeneration and anti-inflammation, and isoquinolinic alkaloids: fat burning signals), specially designed to produce fat burning, and traduce it in an increase of cell energetic metabolism, and a reactivation of the mechanical properties of skin: it reduces the cutaneous lipid content, harnessing the extra energy to rebuild the skin, and to keep each curve in place.

The product is Ecocert certifiable, and free of GSO, BSE, parabens, Phenoxyethanol, pesticides and contaminants.

The applications of the ingredient go from reducers of rebel volumes to cellulite treatments, treatment of double chin, anti-eye bags, lack of tone, contour remodeling, smooth orange skin, firming, treatments for sagging and treatments for specific needs of neck, décolletage and breasts.

Several tests have been performed to validate these claims:

  • In Vitro tests demonstrate the ingredient’s anti-inflammatory and antioxidant properties.
  • Ex Vivo tests on skin explants were performed to proof its Lipolytic effect, skin restructuration and metabolic activation. There was reduction of the lipid content in both the dermis and adipose tissue, indicating a global lipolytic effect in the explants The product also shows an excellent capacity to protect and repair the dermal fibers, that guarantees a restructuring and reaffirmation of the tissue.

In Vivo studies evaluated the firming and slimming effect in face and body, and reshaping effect on ptosis, on volunteers, both in presence and absence of caloric restriction, demonstrating:

  • Facial firmness & elasticity increase despite the diet
  • Body firmness & elasticity increase despite the diet
  • Remodeling effect (Ptosis & sagging reduction)
  • Diet slimming equivalent effect
  • Targeted slimming

In Vivo Evaluation of the FIRMING effect:

  • Double blind study vs. Placebo
  • 30 Volunteers with overweight, BMI (Body Mass Index) 25-30 Kg/m2
  • Two groups of volunteers are established:
  • Group with nutritional monitoring: a moderate reduction in caloric intake
  • Group without nutritional monitoring
  • SARCOSLIM RE-SHAPE PRCF 1.5% dosage
  • Panels of mixed volunteers: 23-29% men and 71-77% women. Age 31-49 years
  • Areas of application: Men: face & abdomen; Women: face & hips Firmness & elasticity measurements by cutometer
  • 56 days – 2 daily applications

Evaluation of Facial and Body Skin Elasticity improvement

SARCOSLIM RE-SHAPE PRCF increased the facial elasticity up to +10 % in the group with NO diet, and increased the facial elasticity up to +10 % in the Diet group, both at 56 days.The same effect was demonstrated with body elasticity, that was increased up to +9.8 % in the No Diet group and up to +7.2 % in the Diet, group at 56 days.

Evaluation of Facial and Body Skin Firmness improvement

SARCOSLIM RE-SHAPE PRCF increased the facial firmness up to +7.6 % in the group without Diet, and up to +14 % in the group with Diet, at 56 days. The ingredient also increased the body firmness up to +8.6 % in No Diet group, and up to +12 % in the Diet group at 56 days.

The studies demonstrate that SARCOSLIM RE-SHAPE PRCF produced significant firming and elasticity boosting effects which were equivalent in intensity both in face and body (hips in women and abdomen in men).

The active ingredient is especially effective in the group with caloric restriction, where skin firming is more challenging, due to weigh loss.

1. In Vivo Evaluation of the SLIMMING effect

  • Simple blind intra-individual study vs. placebo
  • Women with excess local fat in hips
  • BMI (Body Mass Index, Kg/m2) = 23-30 (overweighed without reaching obesity)
  • Group with diet: 16 vol., 20-45 years (35 ± 3), body application
  • Group without diet: 16 vol., 40-55 years (48 ± 1), body application
  • SARCOSLIM RE-SHAPE PRCF 3% dosage
  • Slimming effect: weight control (kg) & perimeter control of thighs (cm)
  • Reshaping effect (group with no diet): Volume of ptosis or sagging in face (ml)
  • Areas of application: hemi-corporal (hips and thighs) vs placebo
  • 56 days – 2 daily applications

Evaluation of the facial remodelling effect

The volunteers were women presenting ptosis or facial sagging, and were asked to maintain stable weight without modifying life habits. Group with No Diet. 15 vol., 40-55 years old (48 ± 1), Hemi-facial application vs. placebo.

IMAGE 1: Reduction of Ptosis volume

SARCOSLIM RE-SHAPE PRCF showed a significant reduction of facial sagging of up to -18%*, showing a clear re-shaping effect.

The measurements were done with FACESCAN, and the color codifies and defines the increase and decrease in volume. In the images it can be observed that the volume reduction indicates a more defined facial contour line, being the reduction of the volume of ptosis (ml) indicated in the blue zone, demonstrating the remodeling effect of SARCOSLIM RE-SHAPE PRCF.

IMAGE 2: Facial Countour Remodeling

Evaluation of the slimming effect

No Diet: reduction of tight perimeter of up to -3cm, with a significant average reduction of -1.4 cm. This test was effective in 100% of volunteers.

Diet: reduction of the thigh perimeter of up to -5.6cm, with a significant average reduction of -3.8 cm*. This test was also effective in 100% of volunteers.

These results demonstrate the ability of the ingredient to perform a targeted slimming effect on specific zones, and there is an effect equivalent to having done a diet of up to -3.75 kg weight loss, demonstrating the synergistic effect with diet.

SOURCE: www.cosmeticsbusiness.com/news